Insular cortex lesions and morphine-induced suppression of conditioned stimulus intake in the rat.
نویسندگان
چکیده
The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin consumption of IC-lesioned rats. The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty.
منابع مشابه
Morphine-induced suppression of conditioned stimulus intake: effects of stimulus type and insular cortex lesions.
Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived innate reward value. Two major findings emerged from this study. First, morphine s...
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عنوان ژورنال:
- Behavioral neuroscience
دوره 123 1 شماره
صفحات -
تاریخ انتشار 2009